INDICATION

1. Panic attack

2. Epilepsy

•Status epilepticus •Lennox-Gastaut syndrome •Infantile spasm •Absence seizure •Myoclonic seizure •Tonic-clonic seizure •Akinetic and atonic seizure •Partial seizure

3. Bipolar affective disorder

4. Drug-induced dyskinesia

5. Choreiform movement

6. Fulgurant pain

7. Tourette's syndrome

8. Resistant depression

9. Nocturnal myoclonus

10. Trigeminal neuralgia 

DOSAGE AND ADMINISTRATION 
Infants and children

• Initial dose: 0.01 - 0.03 mg/kg/day not to exceed 0.05 mg/kg/day.

•Increment dose: not more than 0.25 - 0.5 mg at intervals of 3 days 

•Maintenance dose: 0.1 - 0.2 mg/kg/day 

•Dosing interval: b.i.d. / t.i.d.

•Upto 1 year: 0.25 mg daily in divided dose, increase gradually to 0.5 - 1 mg.

•1 -5 years: 0.25 mg daily in divided dose, increase to 1 - 3 mg.

•5 - 12 years: 0.5 mg daily in divided dose, increase to 3 - 6 mg. 

Adults and elderly

•Initial dose: 1 mg daily in divided dose (Elderly 0.5 mg), not to exceed 1.5 mg/day

•Increment dose: 0.5 - 1 mg at intervals of 3 days •Maintenance dose: 4-8 mg/day

•Maximum dose: 20 mg/day should be administered with caution •Dosing interval: b.i.d. / t.i.d. 
 

Initial dose should be low and increased gradually to a maintenance dose that controls seizure without toxic effects. During discontinuation, the dose should be tapered. 
 

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